Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
نویسندگان
چکیده
منابع مشابه
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to tra...
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The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore, mandatory. Since the seminal observations two decades ago that the Tat protein, and derived peptides, can translocate across biological membr...
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ژورنال
عنوان ژورنال: Journal of Biophysics
سال: 2011
ISSN: 1687-8000,1687-8019
DOI: 10.1155/2011/414729